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KMID : 1145520230090010035
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Journal of Radiopharmaceuticals and Molecular Probes
2023 Volume.9 No. 1 p.35 ~ p.41
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Photodynamic Therapy for Cancer without External Light Illumination by Utilizing Radioisotope-induced Cerenkov Luminescence as an Excitation Source
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Kang Chi-Soo
Saidul Islam
Kim Do-Hyeon
Lee Kyo-Chul
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Abstract
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Photodynamic therapy (PDT), in which a photosensitizer (PS), light, and molecular oxygen are essential components, is a non-invasive and highly effective cancer therapeutic method. However, PDT suffers from the penetration limit of light caused by attenuation and scattering of light through tissues constraining its use to skin and endoscopically accessible cancers. Cerenkov luminescence (CL) is defined as the light illuminated when charged particles move in a dielectric medium at a velocity greater than the phase velocity of light. It is known that medical radioisotopes in preclinical and clinical settings have enough energy to generate CL, and lately, CL has been exploited as an excitation source for PDT without external light illumination. This review introduces state of the art studies of radioisotope-based PDT for cancer, in which radioisotopes are utilized as a light source.
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KEYWORD
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Photodynamic therapy, Cerenkov luminescence energy transfer, Cancer therapeutics, Radioisotopes, Cerenkov luminescence
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